Hydralazine and Isosorbide Dinitrate in Heart Failure

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Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.

BACKGROUND We examined whether a fixed dose of both isosorbide dinitrate and hydralazine provides additional benefit in blacks with advanced heart failure, a subgroup previously noted to have a favorable response to this therapy. METHODS A total of 1050 black patients who had New York Heart Association class III or IV heart failure with dilated ventricles were randomly assigned to receive a f...

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Vasodilator treatment with isosorbide dinitrate and hydralazine in chronic heart failure.

Several reports have suggested that because isosorbide dinitrate and hydralazine have different and additive haemodynamic effects at rest in patients with chronic heart failure, these agents should be administered in combination. Some studies, however, indicate thay they are effective individually as well. Since most patients with heart failure are symptomatic only with activity, we examined th...

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Isosorbide dinitrate plus hydralazine was effective for advanced heart failure in black patients.

and commentary also appear in ACP Journal Club . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr A Taylor, University of Minnesota Medical School, Minneapolis, MN, USA. [email protected] Source of funding: NitroMed. Isosorbide dinitrate plus hydralazine (ID+H) v placebo for heart failure (HF) in black ...

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Postural hypotension and tachycardia during hydralazine--isosorbide dinitrate therapy for chronic heart failure.

Supine and upright hemodynamic measurements were performed in 10 patients with chronic congestive heart failure, before and during vasodilator therapy with hydralazine and isosorbide dinitrate. This combination of drugs produced significant improvement in supine hemodynamic measurements, with the pulmonary capillary wedge pressure decreasing from 26 +/- 5 to 18 +/- 5 mm Hg (mean +/- SD, p less ...

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Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failure

Despite significant improvement in therapy and management, heart failure remains a worrisome disease state that is especially problematic in special populations. African Americans suffer a disproportionately higher prevalence of heart failure when compared to other populations. It has been recently demonstrated that vasodilator therapy using the combination of isosorbide dinitrate (ISDN) and hy...

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ژورنال

عنوان ژورنال: Circulation

سال: 2011

ISSN: 0009-7322,1524-4539

DOI: 10.1161/circulationaha.110.012781